Abstract

intervention compared with usual care. A lifetime Markov cohort model for women with early breast cancer was constructed taking a societal perspective. Data were obtained from trial, epidemiological, quality of life, and healthcare cost reports. Outcomes were calculated from 5000 Monte Carlo simulations, and one-way and probabilistic sensitivity analyses. Over the cohort's remaining life, the incremental cost for the exercise versus usual care groups were $7409 and quality-adjusted life years (QALYs) gained were 0.35 resulting in an incremental cost per QALY ratio of AU$21,247 (95% Uncertainty Interval (UI): Dominant, AU$31,398). The likelihood that the exercise intervention was cost-effective at acceptable levels was 93.0%. The incremental cost per life year gained was AU$8894 (95% UI Dominant, AU$11,769) with a 99.4% probability of being cost effective. Findings were most sensitive to the probability of recurrence in the exercise and usual care groups, followed by the costs of out-of-pocket expenses and the model starting age. This exercise intervention for women after early-stage breast cancer is cost-effective and would be a sound investment of healthcare resources.

Authors	Gordon, Louisa G; Eakin, Elizabeth G; Spence, Rosalind R; Pyke, Christopher; Bashford, John; Saunders, Christobel; Hayes, Sandra C
Journal	International Journal Of Environmental Research And Public Health
Pages
Volume	17
Date	1/11/2020
Grant ID	n/a
Funding Body	National Breast Cancer Foundation
URL	http://www.ncbi.nlm.nih.gov/pubmed/?term=10.3390/ijerph17228608