Abstract

Analysis of whole-genome sequencing data across 2,658 tumors spanning 38 cancer types shows that chromothripsis is pervasive, with a frequency of more than 50% in several cancer types, contributing to oncogene amplification, gene inactivation and cancer genome evolution.

Authors	Cortes-Ciriano, Isidro; Lee, Jake June-Koo; Xi, Ruibin; Jain, Dhawal; Jung, Youngsook L.; Yang, Lixing; Gordenin, Dmitry; Klimczak, Leszek J.; Zhang, Cheng-Zhong; Pellman, David S.; Park, Peter J.; Akdemir, Kadir C.; Alvarez, Eva G.; Baez-Ortega, Adrian; Beroukhim, Rameen; Boutros, Paul C.; Bowtell, David D. L.; Brors, Benedikt; Burns, Kathleen H.; Campbell, Peter J.; Chan, Kin; Chen, Ken; Dueso-Barroso, Ana; Dunford, Andrew J.; Edwards, Paul A.; Estivill, Xavier; Etemadmoghadam, Dariush; Feuerbach, Lars; Fink, J. Lynn; Frenkel-Morgenstern, Milana; Garsed, Dale W.; Gerstein, Mark; Gordenin, Dmitry A.; Haan, David; Haber, James E.; Hess, Julian M.; Hutter, Barbara; Imielinski, Marcin; Jones, David T. W.; Ju, Young Seok; Kazanov, Marat D.; Koh, Youngil; Korbel, Jan O.; Kumar, Kiran; Lee, Eunjung Alice; Li, Yilong; Lynch, Andy G.; Macintyre, Geoff; Markowetz, Florian; Martincorena, Inigo; Martinez-Fundichely, Alexander; Miyano, Satoru; Nakagawa, Hidewaki; Navarro, Fabio C. P.; Ossowski, Stephan; Pearson, John, V; Puiggros, Montserrat; Rippe, Karsten; Roberts, Nicola D.; Roberts, Steven A.; Rodriguez-Martin, Bernardo; Schumacher, Steven E.; Scully, Ralph; Shackleton, Mark; Sidiropoulos, Nikos; Sieverling, Lina; Stewart, Chip; Torrents, David; Tubio, Jose M. C.; Villasante, Izar; Waddell, Nicola; Wala, Jeremiah A.; Weischenfeldt, Joachim; Yao, Xiaotong; Yoon, Sung-Soo; Zamora, Jorge
Journal	NATURE GENETICS
Pages	331-+
Volume	52
Date	1/02/2020
Grant ID	703543
Funding Body	European Union
URL	http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1038/s41588-019-0576-7