Comparative study of preclinical mouse models of high-grade glioma for nanomedicine research: the importance of reproducing blood-brain barrier heterogeneity.
Abstract
The WK1 mouse model more accurately reproduces the extent of BBB disruption, the level of BBB permeability and the histopathological characteristics found in rHGG patients than the U87 mouse model, and is therefore a more clinically relevant model for preclinical evaluations of emerging nanoparticle-based therapies for HGG.
| Authors | Brighi, Caterina; Reid, Lee; Genovesi, Laura A; Kojic, Marija; Millar, Amanda; Bruce, Zara; White, Alison L; Day, Bryan W; Rose, Stephen; Whittaker, Andrew K; Puttick, Simon |
|---|---|
| Journal | THERANOSTICS |
| Pages | 6361-6371 |
| Volume | 10 |
| Date | 1/05/2020 |
| Grant ID | CE140100036 |
| Funding Body | Australia Research Council Centre of Excellence in Bio-Nano Science Technology |
| URL | http://www.ncbi.nlm.nih.gov/pubmed/?term=10.7150/thno.46468 |