. No infectious ZIKV was detected in maternal blood, placenta, or fetal heads in BinJ/ZIKA-prME-vaccinated mice. A similar result was obtained when the more sensitive qRT PCR methodology was used to measure the viral RNA. BinJ/ZIKA-prME vaccination also did not result in antibody-dependent enhancement of dengue virus infection or disease. BinJ/ZIKA-prME thus emerges as a potential vaccine candidate for the prevention of CSZ.
| Authors | Hazlewood, Jessamine E; Rawle, Daniel J; Tang, Bing; Yan, Kexin; Vet, Laura J; Nakayama, Eri; Hobson-Peters, Jody; Hall, Roy A; Suhrbier, Andreas |
|---|---|
| Journal | Vaccines |
| Pages | |
| Volume | 8 |
| Date | 1/09/2020 |
| Grant ID | APP1173880 |
| Funding Body | National Health and Medical Research Council |
| URL | http://www.ncbi.nlm.nih.gov/pubmed/?term=10.3390/vaccines8030496 |