A Peptide-Based PD1 Antagonist Enhances T-Cell Priming and Efficacy of a Prophylactic Malaria Vaccine and Promotes Survival in a Lethal Malaria Model.
Abstract
regulatory T cells. Taken together, our results demonstrate that LD01 is a potent immunomodulator that acts upon the adaptive immune system to stimulate T cell responses both prophylactically and therapeutically.
| Authors | Phares, Timothy W; Kotraiah, Vinayaka; Karunarathne, Deshapriya S; Huang, Jing; Browne, Cecille D; Buontempo, Peter; Mansour, Marc; Noe, Amy R; Wykes, Michelle N; Pannucci, James; Tsuji, Moriya; Gutierrez, Gabriel M |
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| Journal | Frontiers in Immunology |
| Pages | 1377 |
| Volume | 11 |
| Date | 1/07/2020 |
| Grant ID | AID-OAA-C-15-00071 |
| Funding Body | Office of Infectious Diseases, Bureau for Global Health, U.S. Agency for International Development |
| URL | http://www.ncbi.nlm.nih.gov/pubmed/?term=10.3389/fimmu.2020.01377 |