Abstract

BACKGROUND: mutant cancers. METHODS: mouse, respectively. RESULTS: ), compared to animals with Apc or Braf mutation alone. CONCLUSIONS: the WNT signaling axis is frequently mutated in BRAF mutant colorectal cancers. WNT16 and MEN1 may be novel drivers of aberrant WNT signaling in colorectal cancer. Co-mutation of BRAF and APC generates an extremely aggressive neoplastic phenotype that is associated with poor patient outcome.

Authors	Fennell, Lochlan J; Kane, Alexandra; Liu, Cheng; McKeone, Diane; Fernando, Winnie; Su, Chang; Bond, Catherine; Jamieson, Saara; Dumenil, Troy; Patch, Ann-Marie; Kazakoff, Stephen H; Pearson, John V; Waddell, Nicola; Leggett, Barbara; Whitehall, Vicki L J
Journal	Cancers
Pages
Volume	12
Date	1/05/2020
Grant ID	1050455
Funding Body	National Health and Medical Research Council
URL	http://www.ncbi.nlm.nih.gov/pubmed/?term=10.3390/cancers12051171