Abstract

antigen persistence was associated with an interferon-high and T-cell-rich tumor microenvironment, allowing for immune checkpoint inhibition as salvage therapy. Thus, the choice of target antigen determines the phenotype and immune contexture of recurrent melanomas, with implications to the design of cancer immunotherapies.

Authors	Effern, Maike; Glodde, Nicole; Braun, Matthias; Liebing, Jana; Boll, Helena N; Yong, Michelle; Bawden, Emma; Hinze, Daniel; van den Boorn-Konijnenberg, Debby; Daoud, Mila; Aymans, Pia; Landsberg, Jennifer; Smyth, Mark J; Flatz, Lukas; Tüting, Thomas; Bald, Tobias; Gebhardt, Thomas; Hölzel, Michael
Journal	IMMUNITY
Pages	564-580.e9
Volume	53
Date	1/07/2020
Grant ID	1124690
Funding Body	NHMRC Early Career Fellowship
URL	http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1016/j.immuni.2020.07.007
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