Abstract

BACKGROUND: A-methylation in hepatocellular carcinoma (HCC). RESULTS: A-containing interleukin 11 (IL11) and serpin family E member 2 (SERPINE2) mRNAs, which were responsible for the inflammation-mediated malignancy and disruption of vascular normalization. Reciprocally, YTHDF2 transcription succumbed to hypoxia-inducible factor-2a (HIF-2a). Administration of a HIF-2a antagonist (PT2385) restored YTHDF2-programed epigenetic machinery and repressed liver cancer. CONCLUSION: A-mRNA landscape in human HCC and revealed YTHDF2 as a molecular 'rheostat' in epitranscriptome and cancer progression.

Authors	Hou, Jiajie; Zhang, He; Liu, Jun; Zhao, Zhenjun; Wang, Jianye; Lu, Zhike; Hu, Bian; Zhou, Jiankui; Zhao, Zhicong; Feng, Mingxuan; Zhang, Haiyan; Shen, Bin; Huang, Xingxu; Sun, Beicheng; He, Chuan; Xia, Qiang
Journal	MOLECULAR CANCER
Pages	163
Volume	18
Date	1/11/2019
Grant ID	2017YFC0908102
Funding Body	National Key Research and Development Program of China
URL	http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1186/s12943-019-1082-3
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