Stachyonic acid A, arising from the first in-depth phytochemical investigation of the herb Basilicum polystachyon, was found to display potent inhibitory activity against dengue virus, with limited cytotoxicity. Andrographolide, a known dengue virus inhibitor and closely related labdane-type diterpene, is structurally more complex but displayed poor antiviral activity in the PRNT assay, and increased cytotoxicity in comparison. Furthermore, a Diels-Alder reaction with PTAD identified the active pharmacophore of stachyonic acid to be the conjugated diene.
| Authors | Tan, Yuen P; Houston, Sevan D; Modhiran, Naphak; Savchenko, Andrei I; Boyle, Glen M; Young, Paul R; Watterson, Daniel; Williams, Craig M |
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| Journal | Chemistry (Weinheim An Der Bergstrasse, Germany) |
| Pages | 5664-5667 |
| Volume | 25 |
| Date | 1/03/2019 |
| Grant ID | |
| Funding Body | University of Queensland (UQ) |
| URL | http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1002/chem.201900591 |