QIMR Berghofer

New Casbanes and the First trans-Cyclopropane seco-Casbane from the Australian Rainforest Plant Croton insularis.


C NMR data. Comparison of the experimental electronic circular dichroism (ECD) spectra with the theoretical curves, calculated by TD-DFT at the B3LYP/6-31+G**//B3LYP/6-31+G** level, in conjunction with NOE data afforded the absolute configuration. EBC-180, 181 and 220 displayed potent activity against cervical carcinoma (HeLa cells).

Authors Maslovskaya, Lidiya A; Savchenko, Andrei I; Pierce, Carly J; Boyle, Glen M; Gordon, Victoria A; Reddell, Paul W; Parsons, Peter G; Williams, Craig M
Journal Chemistry (Weinheim An Der Bergstrasse, Germany)
Pages 1525-1534
Volume 25
Date 1/01/2019
Grant ID
Funding Body EcoBiotics Ltd.
URL http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1002/chem.201804904