Abstract

). Pathway analysis showed that the three phosphatidylcholines and methionine are involved in homocysteine metabolism and we found supporting evidence for an association of lipid metabolism with LTL. In conclusion, we found longer LTL associated with higher levels of lysoPC a C17:0 and PC ae C38:4, and with lower levels of methionine, tyrosine, PC aa C32:1, and C3-OH. These metabolites have been implicated in inflammation, oxidative stress, homocysteine metabolism, and in cardiovascular disease and diabetes, two major drivers of morbidity and mortality.

Authors	van der Spek, Ashley; Broer, Linda; Draisma, Harmen H M; Pool, René; Albrecht, Eva; Beekman, Marian; Mangino, Massimo; Raag, Mait; Nyholt, Dale R; Dharuri, Harish K; Codd, Veryan; Amin, Najaf; de Geus, Eco J C; Deelen, Joris; Demirkan, Ayse; Yet, Idil; Fischer, Krista; Haller, Toomas; Henders, Anjali K; Isaacs, Aaron; Medland, Sarah E; Montgomery, Grant W; Mooijaart, Simon P; Strauch, Konstantin; Suchiman, H Eka D; Vaarhorst, Anika A M; van Heemst, Diana; Wang-Sattler, Rui; Whitfield, John B; Willemsen, Gonneke; Wright, Margaret J; Martin, Nicholas G; Samani, Nilesh J; Metspalu, Andres; Eline Slagboom, P; Spector, Tim D; Boomsma, Dorret I; van Duijn, Cornelia M; Gieger, Christian
Journal	SCIENTIFIC REPORTS
Pages	11623
Volume	9
Date	1/08/2019
Grant ID	619667
Funding Body	Department of Health | National Health and Medical Research Council (NHMRC)
URL	http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1038/s41598-019-47282-6
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