Abstract

?=?0.62). Skin colour (measured both ordinally and quantitatively) and self-reported sun exposure were found to significantly affect 25(OH)D3 concentration. Twins with olive/dark skin had significantly lower 25(OH)D3 concentrations than those with fair/pale skin and multivariate genetic analysis showed that approximately half of the total additive genetic variation in 25(OH)D3 results from genes whose primary influence is on skin colour and sun exposure. Additionally, 37% of the total variance was attributed to shared environmental effects on vitamin D, skin colour and sun exposure measures. These results support a moderate estimate of vitamin D heritability and suggest significant influence of season, skin colour and sun exposure on the genetic variance.

Authors	Mitchell, Brittany L; Zhu, Gu; Medland, Sarah E; Renteria, Miguel E; Eyles, Darryl W; Grasby, Katrina L; McGrath, John J; Martin, Nicholas G
Journal	BEHAVIOR GENETICS
Pages	386-398
Volume	49
Date	1/03/2019
Grant ID	241944, 552485, 552498, 1031119, 1049894
Funding Body	National Health and Medical Research Council
URL	http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1007/s10519-019-09954-x
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