Abstract

and the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED) and conduct a genome-wide association study of 16,992?cases of anorexia nervosa and 55,525?controls, identifying eight significant loci. The genetic architecture of anorexia nervosa mirrors its clinical presentation, showing significant genetic correlations with psychiatric disorders, physical activity, and metabolic (including glycemic), lipid and anthropometric traits, independent of the effects of common variants associated with body-mass index. These results further encourage a reconceptualization of anorexia nervosa as a metabo-psychiatric disorder. Elucidating the metabolic component is a critical direction for future research, and paying attention to both psychiatric and metabolic components may be key to improving outcomes.

Authors	Watson, Hunna J; Yilmaz, Zeynep; Thornton, Laura M; Hübel, Christopher; Coleman, Jonathan R I; Gaspar, Héléna A; Bryois, Julien; Hinney, Anke; Leppä, Virpi M; Mattheisen, Manuel; Medland, Sarah E; Ripke, Stephan; Yao, Shuyang; Giusti-Rodríguez, Paola; , ; Hanscombe, Ken B; Purves, Kirstin L; , ; Adan, Roger A H; Alfredsson, Lars; Ando, Tetsuya; Andreassen, Ole A; Baker, Jessica H; Berrettini, Wade H; Boehm, Ilka; Boni, Claudette; Perica, Vesna Boraska; Buehren, Katharina; Burghardt, Roland; Cassina, Matteo; Cichon, Sven; Clementi, Maurizio; Cone, Roger D; Courtet, Philippe; Crow, Scott; Crowley, James J; Danner, Unna N; Davis, Oliver S P; de Zwaan, Martina; Dedoussis, George; Degortes, Daniela; DeSocio, Janiece E; Dick, Danielle M; Dikeos, Dimitris; Dina, Christian; Dmitrzak-Weglarz, Monika; Docampo, Elisa; Duncan, Laramie E; Egberts, Karin; Ehrlich, Stefan; Escaramís, Geòrgia; Esko, Tõnu; Estivill, Xavier; Farmer, Anne; Favaro, Angela; Fernández-Aranda, Fernando; Fichter, Manfred M; Fischer, Krista; Föcker, Manuel; Foretova, Lenka; Forstner, Andreas J; Forzan, Monica; Franklin, Christopher S; Gallinger, Steven; Giegling, Ina; Giuranna, Johanna; Gonidakis, Fragiskos; Gorwood, Philip; Mayora, Monica Gratacos; Guillaume, Sébastien; Guo, Yiran; Hakonarson, Hakon; Hatzikotoulas, Konstantinos; Hauser, Joanna; Hebebrand, Johannes; Helder, Sietske G; Herms, Stefan; Herpertz-Dahlmann, Beate; Herzog, Wolfgang; Huckins, Laura M; Hudson, James I; Imgart, Hartmut; Inoko, Hidetoshi; Janout, Vladimir; Jiménez-Murcia, Susana; Julià, Antonio; Kalsi, Gursharan; Kaminská, Deborah; Kaprio, Jaakko; Karhunen, Leila; Karwautz, Andreas; Kas, Martien J H; Kennedy, James L; Keski-Rahkonen, Anna; Kiezebrink, Kirsty; Kim, Youl-Ri; Klareskog, Lars; Klump, Kelly L; Knudsen, Gun Peggy S; La Via, Maria C; Le Hellard, Stephanie; Levitan, Robert D; Li, Dong; Lilenfeld, Lisa; Lin, Bochao Danae; Lissowska, Jolanta; Luykx, Jurjen; Magistretti, Pierre J; Maj, Mario; Mannik, Katrin; Marsal, Sara; Marshall, Christian R; Mattingsdal, Morten; McDevitt, Sara; McGuffin, Peter; Metspalu, Andres; Meulenbelt, Ingrid; Micali, Nadia; Mitchell, Karen; Monteleone, Alessio Maria; Monteleone, Palmiero; Munn-Chernoff, Melissa A; Nacmias, Benedetta; Navratilova, Marie; Ntalla, Ioanna; O'Toole, Julie K; Ophoff, Roel A; Padyukov, Leonid; Palotie, Aarno; Pantel, Jacques; Papezova, Hana; Pinto, Dalila; Rabionet, Raquel; Raevuori, Anu; Ramoz, Nicolas; Reichborn-Kjennerud, Ted; Ricca, Valdo; Ripatti, Samuli; Ritschel, Franziska; Roberts, Marion; Rotondo, Alessandro; Rujescu, Dan; Rybakowski, Filip; Santonastaso, Paolo; Scherag, André; Scherer, Stephen W; Schmidt, Ulrike; Schork, Nicholas J; Schosser, Alexandra; Seitz, Jochen; Slachtova, Lenka; Slagboom, P Eline; Slof-Op 't Landt, Margarita C T; Slopien, Agnieszka; Sorbi, Sandro; Swiatkowska, Beata; Szatkiewicz, Jin P; Tachmazidou, Ioanna; Tenconi, Elena; Tortorella, Alfonso; Tozzi, Federica; Treasure, Janet; Tsitsika, Artemis; Tyszkiewicz-Nwafor, Marta; Tziouvas, Konstantinos; van Elburg, Annemarie A; van Furth, Eric F; Wagner, Gudrun; Walton, Esther; Widen, Elisabeth; Zeggini, Eleftheria; Zerwas, Stephanie; Zipfel, Stephan; Bergen, Andrew W; Boden, Joseph M; Brandt, Harry; Crawford, Steven; Halmi, Katherine A; Horwood, L John; Johnson, Craig; Kaplan, Allan S; Kaye, Walter H; Mitchell, James E; Olsen, Catherine M; Pearson, John F; Pedersen, Nancy L; Strober, Michael; Werge, Thomas; Whiteman, David C; Woodside, D Blake; Stuber, Garret D; Gordon, Scott; Grove, Jakob; Henders, Anjali K; Juréus, Anders; Kirk, Katherine M; Larsen, Janne T; Parker, Richard; Petersen, Liselotte; Jordan, Jennifer; Kennedy, Martin; Montgomery, Grant W; Wade, Tracey D; Birgegård, Andreas; Lichtenstein, Paul; Norring, Claes; Landén, Mikael; Martin, Nicholas G; Mortensen, Preben Bo; Sullivan, Patrick F; Breen, Gerome; Bulik, Cynthia M
Journal	NATURE GENETICS
Pages	1207-+
Volume	51
Date	1/07/2019
Grant ID
Funding Body	National Institute of Mental Health
URL	http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1038/s41588-019-0439-2
	Download Article