Concordance of genetic variation that increases risk for tourette syndrome and that influences its underlying neurocircuitry.
Abstract
) when conditioning on intracranial (rs2708146, q?=?0.046; and rs72853320, q?=?0.035) and hippocampal (rs1922786, q?=?0.001) volumes, respectively. These data indicate concordance for genetic variation involved in disorder risk and subcortical brain volumes in TS. Further work with larger samples is needed to fully delineate the genetic architecture of these disorders and their underlying neurocircuitry.
| Authors | Mufford, Mary; Cheung, Josh; Jahanshad, Neda; van der Merwe, Celia; Ding, Linda; Groenewold, Nynke; Koen, Nastassja; Chimusa, Emile R; Dalvie, Shareefa; Ramesar, Raj; , ; Knowles, James A; Lochner, Christine; Hibar, Derrek P; Paschou, Peristera; van den Heuvel, Odile A; Medland, Sarah E; Scharf, Jeremiah M; Mathews, Carol A; Thompson, Paul M; Stein, Dan J |
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| Journal | TRANSLATIONAL PSYCHIATRY |
| Pages | 120 |
| Volume | 9 |
| Date | 1/03/2019 |
| Grant ID | U54 EB020403 |
| Funding Body | Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) |
| URL | http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1038/s41398-019-0452-3 |
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