Concordance of genetic variation that increases risk for anxiety disorders and posttraumatic stress disorders and that influences their underlying neurocircuitry
Abstract
Background: There have been considerable recent advances in understanding the genetic architecture of anxiety disorders and posttraumatic stress disorder (PTSD), as well as the underlying neurocircuitry of these disorders. However, there is little work on the concordance of genetic variations that increase risk for these conditions, and that influence subcortical brain structures. We undertook a genome-wide investigation of the overlap between the genetic influences from single nucleotide polymorphisms (SNPs) on volumes of subcortical brain structures and genetic risk for anxiety disorders and PTSD.
| Authors | van der Merwe, Celia; Jahanshad, Neda; Cheung, Josh W.; Mufford, Mary; Groenewold, Nynke A.; Koen, Nastassja; Ramesar, Rajkumar; Dalvie, Shareefa; Knowles, James A.; Hibar, Derrek P.; Nievergelt, Caroline M.; Koenen, Karestan C.; Liberzon, Israel; Ressler, Kerry J.; Medland, Sarah E.; Morey, Rajendra A.; Thompson, Paul M.; Stein, Dan J. |
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| Journal | JOURNAL OF AFFECTIVE DISORDERS |
| Pages | 885-896 |
| Volume | 245 |
| Date | 1/02/2019 |
| Grant ID | U54 EB020403 |
| Funding Body | NIH |
| URL | http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1016/j.jad.2018.11.082 |