Abstract

showed very strong but selective binding, specifically to the alpha-1 target which would be evolutionarily selected for, as well as the alpha-5 target which is of major interest for drug design and development. Thus, we have shown that our novel method is broadly applicable for studies including evolutionary patterns of venom diversification, predicting potential neurotoxic effects in human envenomed patients, and searches for novel ligands of interest for laboratory tools and in drug design and development.

Authors	Zdenek, Christina N; Harris, Richard J; Kuruppu, Sanjaya; Youngman, Nicholas J; Dobson, James S; Debono, Jordan; Khan, Muzaffar; Smith, Ian; Yarski, Mike; Harrich, David; Sweeney, Charlotte; Dunstan, Nathan; Allen, Luke; Fry, Bryan G
Journal	Toxins
Pages
Volume	11
Date	1/10/2019
Grant ID	DP190100304
Funding Body	Australian Research Council
URL	http://www.ncbi.nlm.nih.gov/pubmed/?term=10.3390/toxins11100600