Abstract

IMPORTANCE Although the usefulness of polygenic risk scores as a measure of genetic liability for major depression (MD) has been established, their association with depression in the general population remains relatively unexplored.

Authors	Musliner, Katherine L.; Mortensen, Preben B.; McGrath, John J.; Suppli, Nis P.; Hougaard, David M.; Bybjerg-Grauholm, Jonas; Baekvad-Hansen, Marie; Andreassen, Ole; Pedersen, Carsten B.; Pedersen, Marianne G.; Mors, Ole; Nordentoft, Merete; Borglum, Anders D.; Werge, Thomas; Agerbo, Esben; Stahl, Eli A.; Breen, Gerome; Forstner, Andreas J.; McQuillin, Andrew; Ripke, Stephan; Trubetskoy, Vassily; Mattheisen, Manuel; Wang, Yunpeng; Coleman, Jonathan R., I; Gaspar, Helena A.; de Leeuw, Christiaan A.; Steinberg, Stacy; Pavlides, Jennifer M. Whitehead; Trzaskowski, Maciej; Pers, Tune H.; Holmans, Peter A.; Abbott, Liam; Agerbo, Esben; Akil, Huda; Albani, Diego; Alliey-Rodriguez, Ney; Als, Thomas D.; Anjorin, Adebayo; Antilla, Verneri; Awasthi, Swapnil; Badner, Judith A.; Etzekvad-Hansen, Marie; Barchas, Jack D.; Bass, Nicholas; Bauer, Michael; Belliveau, Richard; Bergen, Sarah E.; Pedersen, Carsten Bocker; Boen, Erlend; Boks, Marco; Boocock, James; Budde, Monika; Bunney, William; Burmeister, Margit; Bybjerg-Grauholm, Jonas; Byerley, William; Casas, Miguel; Cerrato, Felecia; Cervantes, Pablo; Chambert, Kimberly; Chamey, Alexander W.; Chen, Danfeng; Churchhouse, Claire; Clarke, Toni-Kim; Coryell, William; Craig, David W.; Cruceanu, Cristiana; Curtis, David; Czerski, Piotr M.; Dale, Anders M.; de Jong, Simone; Degenhardt, Franziska; Del-Favero, Jurgen; DePaulo, J. Raymond; Djurovic, Srdjan; Dobbyn, Amanda L.; Dumont, Ashley; Elvsashagen, Torbjorn; Escott-Price, Valentina; Fan, Chun Chieh; Fischer, Sascha B.; Flickinger, Matthew; Foroud, Tatiana M.; Forty, Liz; Frank, Josef; Fraser, Christine; Freimer, Nelson B.; Frisen, Louise; Gade, Katrin; Gage, Diane; Garnham, Julie; Giambartobmei, Claudia; Pedersen, Marianne Giortz; Goldstein, Jaqueline; Gordon, Scott D.; Gordon-Smith, Katherine; Green, Elaine K.; Green, Melissa J.; Greenwood, Tiffany A.; Grove, Jakob; Guan, Weihua; Parra, Jose Guzman; Hamshere, Marian L.; Hautzinger, Martin; Heilbronner, Urs; Herms, Stefan; Hipolito, Maria; Hoffmann, Per; Holland, Dominic; Huckins, Laura; Jamain, Stephan; Johnson, Jessica S.; Jureus, Anders; Kandaswamy, Radhika; Karlsson, Robert; Kennedy, James L.; Kittel-Schneider, Sarah; Knott, Sarah, V; Knowles, James A.; Kogevinas, Manolis; Koller, Anna C.; Kupka, Ralph; Lavebratt, Catharina; Lawrence, Jacob; Lawson, William B.; Leber, Markus; Lee, Phil H.; Levy, Shawn E.; Li, Jun Z.; Liu, Chunyu; Lucae, Susanne; Maaser, Anna; MacIntyre, Donald J.; Mahon, Pamela B.; Maier, Wolfgang; Martinsson, Lina; McCarroll, Steve; McGuffin, Peter; McInnis, Melvin G.; McKay, James D.; Medeiros, Helena; Medland, Sarah E.; Meng, Fan; Milani, Lili; Montgomery, Grant W.; Morris, Derek W.; Muehleisen, Thomas W.; Mullins, Niamh; Nguyen, Hoang; Nievergelt, Caroline M.; Adolfsson, Annelie Nordin; Nwulia, Evaristus A.; O'Donovan, Claire; Loohuis, Loes M. Olde; Ori, Anil P. S.; Oruc, Lilijana; Osby, Urban; Perlis, Roy H.; Perry, Amy; Pfennig, Andrea; Potash, James B.; Purcell, Shaun M.; Regeer, Eline J.; Reif, Andreas; Reinbold, Celine S.; Rice, John P.; Rivas, Fabio; Rivera, Margarita; Roussos, Panos; Ruderfer, Douglas M.; Ryu, Euijung; Sanchez-Mora, Cristina; Schatzberg, Alan F.; Scheftner, William A.; Schork, Nicholas J.; Weickert, Cynthia Shannon; Shehktman, Tatyana; Shilling, Paul D.; Sigurdsson, Engilbert; Slaney, Claire; Smeland, Olav B.; Sobell, Janet L.; Hansen, Christine Soholm; Spijker, Anne T.; St Clair, David; Steffens, Michael; Strauss, John S.; Streit, Fabian; Strohmaier, Jana; Szelinger, Szabolcs; Thompson, Robert C.; Thorgeirsson, Thorgeir E.; Treutlein, Jens; Vedder, Helmut; Wang, Weiqing; Watson, Stanley J.; Weickert, Thomas W.; Witt, Stephanie H.; Xi, Simon; Xu, Wei; Young, Allan H.; Zandi, Peter; Zhang, Peng; Zollner, Sebastian; Agartz, Ingrid; Aida, Martin; Backlund, Lena; Baune, Bernhard T.; Bellivier, Frank; Berrettini, Wade H.; Biemacka, Joanna M.; Blackwood, Douglas H. R.; Boehnke, Michael; Berglum, Anders D.; Corvin, Aiden; Craddock, Nicholas; Daly, Mark J.; Dannlowski, Udo; Esko, Tonu; Etain, Bruno; Frye, Mark; Fullerton, Janice M.; Gershon, Elliot S.; Goes, Fernando; Grigoroiu-Serbanescu, Maria; Hauser, Joanna; Hougaard, David M.; Hultman, Christina M.; Jones, Ian; Jones, Lisa A.; Kahn, Rene S.; Kirov, George; Landen, Mikael; Leboyer, Marion; Lewis, Cathryn M.; Li, Qingqin S.; Lissowska, Jolanta; Martin, Nicholas G.; Mayoral, Fermin; McElroy, Susan L.; McIntosh, Andrew M.; McMahon, Francis J.; Melle, Ingrid; Metspalu, Andres; Mitchell, Philip B.; Morken, Gunnar; Mors, Ole; Mortensen, Preben Bo; Mueller-Myhsok, Bertram; Myers, Richard M.; Neale, Benjamin M.; Nimgaonkar, Vishwajit; Nordentoft, Merete; Noethen, Markus M.; O'Donovan, Michael C.; Oedegaard, Ketil J.; Owen, Michael; Paciga, Sara A.; Pato, Carlos; Pato, Michele T.; Posthuma, Danielle; Ramos-Quiroga, Josep Antoni; Ribases, Marta; Rietschel, Marcella; Rouleau, Guy A.; Schalling, Martin; Schofield, Peter R.; Schulze, Thomas G.; Serretti, Alessandro; Smoller, Jordan W.; Stefansson, Hreinn; Stefansson, Kari; Stordal, Eystein; Sullivan, Patrick F.; Turecki, Gustavo; Vaaler, Arne E.; Ieta, Eduard, V; Vincent, John B.; Werge, Thomas; Nurnberger, John, I; Wray, Naomi R.; Di Florio, Arianna; Edenberg, Howard J.; Cichon, Sven; Ophoff, Roel A.; Scott, Laura J.; Andreassen, Ole A.; Kelsoe, John; Sklar, Pamela
Journal	JAMA PSYCHIATRY
Pages	516-525
Volume	76
Date	1/05/2019
Grant ID	R155-2014-1724
Funding Body	Lundbeck Foundation
URL	http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1001/jamapsychiatry.2018.4166
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