QIMR Berghofer

A recombinant platform for flavivirus vaccines and diagnostics using chimeras of a new insect-specific virus.

Abstract

mouse models). BinJ/VIF-prME viruses thus represent a versatile, noninfectious (for vertebrate cells), high-yield technology for generating chimeric flavivirus particles with low biocontainment requirements.

Authors Hobson-Peters, Jody; Harrison, Jessica J; Watterson, Daniel; Hazlewood, Jessamine E; Vet, Laura J; Newton, Natalee D; Warrilow, David; Colmant, Agathe M G; Taylor, Carmel; Huang, Bixing; Piyasena, Thisun B H; Chow, Weng Kong; Setoh, Yin Xiang; Tang, Bing; Nakayama, Eri; Yan, Kexin; Amarilla, Alberto A; Wheatley, Sarah; Moore, Peter R; Finger, Mitchell; Kurucz, Nina; Modhiran, Naphak; Young, Paul R; Khromykh, Alexander A; Bielefeldt-Ohmann, Helle; Suhrbier, Andreas; Hall, Roy A
Journal Science Translational Medicine
Pages
Volume 11
Date 1/12/2019
Grant ID APP1138611
Funding Body Australian Government National Health and Medical Research Council (NHMRC)
URL http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1126/scitranslmed.aax7888