Abstract

Purpose: To determine if a circulating microRNA (miRNA) panel could be used to distinguish between uveal melanoma and uveal nevi. Methods: = 5). Levels of 17 miRNAs were measured in blood samples of study participants using a sensitive real-time PCR system. Results: < 0.0001; area under the curve = 0.96). When the six-miRNA panel was evaluated as a group it had the ability to identify uveal melanoma when four or more miRNAs (93% sensitivity and 100% specificity) reached or exceeded their cut-point. Conclusions: This miRNA panel, in tandem with clinical findings, may be suited to confirm benign lesions. In addition, due to the panel's high precision in identifying malignancy, it has the potential to augment melanoma detection in subsequent clinical follow-up of lesions with atypical clinical features. Translational Relevance: Uveal nevi mimic the appearance of uveal melanoma and their transformation potential cannot be definitively determined without a biopsy. This panel is most relevant at the nevus stage and in lesions with uncertain malignant potential as a companion diagnostic tool to assist in clinical decision-making.

Authors	Stark, Mitchell S; Gray, Elin S; Isaacs, Timothy; Chen, Fred K; Millward, Michael; McEvoy, Ashleigh; Zaenker, Pauline; Ziman, Melanie; Soyer, H Peter; Glasson, William J; Warrier, Sunil K; Stark, Andrew L; Rolfe, Olivia J; Palmer, Jane M; Hayward, Nicholas K
Journal	Translational vision science & technology
Pages	12
Volume	8
Date	1/11/2019
Grant ID
Funding Body	National Health and Medical Research Council (NHMRC) of Australia
URL	http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1167/tvst.8.6.12