Panel sequencing of 264 candidate susceptibility genes and segregation analysis in a cohort of non-BRCA1, non-BRCA2 breast cancer families

Abstract

The main aim of this study was to screen epigenetic modifier genes and known breast cancer driver genes for germline mutations in non-BRCA1/2 (BRCAx) breast cancer families in order to identify novel susceptibility genes of moderate-high penetrance.

Authors Li, Jun; Li, Hongyan; Makunin, Igor; Thompson, Bryony A.; Tao, Kayoko; Young, Erin L.; Lopez, Jacqueline; Camp, Nicola J.; Tavtigian, Sean V.; John, Esther M.; Andrulis, Irene L.; Khanna, Kum Kum; Goldgar, David; Chenevix-Trench, Georgia
Journal BREAST CANCER RESEARCH AND TREATMENT
Pages 937-949
Volume 166
Date 1/12/2017
Grant ID
Funding Body NHMRC
URL http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1007/s10549-017-4469-0