QIMR Berghofer

Immune checkpoint blockade in infectious diseases.


The upregulation of immune checkpoint molecules, such as programmed cell death protein 1 (PD1) and cytotoxic T lymphocyte antigen 4 (CTLA4), on immune cells occurs during acute infections, such as malaria, as well as during chronic persistent viral infections, including HIV and hepatitis B virus. These pathways are important for preventing immune-driven pathology but can also limit immune-mediated clearance of the infection. The recent success of immune checkpoint blockade in cancer therapy suggests that targeting these pathways would also be effective for preventing and treating a range of infectious diseases. Here, we review our current understanding of immune checkpoint pathways in the pathogenesis of infectious diseases and discuss the potential for therapeutically targeting these pathways in this setting.

Authors Wykes, Michelle N; Lewin, Sharon R
Journal Nature reviews. Immunology
Pages 91-104
Volume 18
Date 1/10/2017
Grant ID
Funding Body National Health and Medical Research Council (NHMRC) (Australia)
URL http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1038/nri.2017.112