Myopia prevalence has increased in the past 20 years, with many studies linking the increase to reduced time spent outdoors. A number of recent observational studies have shown an inverse association between vitamin D [25(OH)D] serum levels and myopia. However, in such studies it is difficult to separate the effects of time outdoors and vitamin D levels. In this work we use Mendelian randomization (MR) to assess if genetically determined 25(OH)D levels contribute to the degree of myopia.
| Authors | Cuellar-Partida, Gabriel; Williams, Katie M.; Yazar, Seyhan; Guggenheim, Jeremy A.; Hewitt, Alex W.; Williams, Cathy; Wang, Jie Jin; Kho, Pik-Fang; Saw, Seang Mei; Cheng, Ching-Yu; Wong, Tien Yin; Aung, Tin; Young, Terri L.; Tideman, J. Willem L.; Jonas, Jost B.; Mitchell, Paul; Wojciechowski, Robert; Stambolian, Dwight; Hysi, Pirro; Hammond, Christopher J.; Mackey, David A.; Lucas, Robyn M.; MacGregor, Stuart |
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| Journal | INTERNATIONAL JOURNAL OF EPIDEMIOLOGY |
| Pages | 1882-1890 |
| Volume | 46 |
| Date | 1/12/2017 |
| Grant ID | |
| Funding Body | University of Queensland |
| URL | http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1093/ije/dyx068 |