Genetically low vitamin D concentrations and myopic refractive error: a Mendelian randomization study


Myopia prevalence has increased in the past 20 years, with many studies linking the increase to reduced time spent outdoors. A number of recent observational studies have shown an inverse association between vitamin D [25(OH)D] serum levels and myopia. However, in such studies it is difficult to separate the effects of time outdoors and vitamin D levels. In this work we use Mendelian randomization (MR) to assess if genetically determined 25(OH)D levels contribute to the degree of myopia.

Authors Cuellar-Partida, Gabriel; Williams, Katie M.; Yazar, Seyhan; Guggenheim, Jeremy A.; Hewitt, Alex W.; Williams, Cathy; Wang, Jie Jin; Kho, Pik-Fang; Saw, Seang Mei; Cheng, Ching-Yu; Wong, Tien Yin; Aung, Tin; Young, Terri L.; Tideman, J. Willem L.; Jonas, Jost B.; Mitchell, Paul; Wojciechowski, Robert; Stambolian, Dwight; Hysi, Pirro; Hammond, Christopher J.; Mackey, David A.; Lucas, Robyn M.; MacGregor, Stuart
Pages 1882-1890
Volume 46
Date 1/12/2017
Grant ID
Funding Body University of Queensland