Dose-Response Association of CD8(+) Tumor-Infiltrating Lymphocytes and Survival Time in High-Grade Serous Ovarian Cancer

Abstract

IMPORTANCE. Cytotoxic CD8(+) tumor-infiltrating lymphocytes (TILs) participate in immune control of epithelial ovarian cancer; however, little is known about prognostic patterns of CD8(+) TILs by histotype and in relation to other clinical factors. OBJECTIVE To define the prognostic role of CDS TILs in epithelial ovarian cancer.

Authors Goode, Ellen L.; Block, Matthew S.; Kalli, Kimberly R.; Vierkant, Robert A.; Chen, Wenqian; Fogarty, Zachary C.; Gentry-Maharaj, Aleksandra; Toloczko, Aleksandra; Hein, Alexander; Bouligny, Aliecia L.; Jensen, Allan; Osorio, Ana; Hartkopf, Andreas D.; Ryan, Andy; Chudecka-Glaz, Anita; Magliocco, Anthony M.; Hartmann, Arndt; Jung, Audrey Y.; Gao, Bo; Hernandez, Brenda Y.; Fridley, Brooke L.; McCauley, Bryan M.; Kennedy, Catherine J.; Wang, Chen; Karpinskyj, Chloe; de Sousa, Christiani B.; Tiezzi, Daniel G.; Wachter, David L.; Herpel, Esther; Taran, Florin Andrei; Modugno, Francesmary; Nelson, Gregg; Lubinski, Jan; Menkiszak, Janusz; Alsop, Jennifer; Lester, Jenny; Garcia-Donas, Jesus; Nation, Jill; Hung, Jillian; Palacios, Jose; Rothstein, Joseph H.; Kelley, Joseph L.; de Andrade, Jurandyr M.; Robles-Diaz, Luis; Intermaggio, Maria P.; Widschwendter, Martin; Beckmann, Matthias W.; Ruebner, Matthias; Jimenez-Linan, Mercedes; Singh, Naveena; Oszurek, Oleg; Harnett, Paul R.; Rambau, Peter F.; Sinn, Peter; Wagner, Philipp; Ghatage, Prafull; Sharma, Raghwa; Edwards, Robert P.; Ness, Roberta B.; Orsulic, Sandra; Brucker, Sara Y.; Johnatty, Sharon E.; Longacre, Teri A.; Eilber, Ursula; McGuire, Valerie; Sieh, Weiva; Natanzon, Yanina; Li, Zheng; Whittemore, Alice S.; deFazio, Anna; Staebler, Annette; Karlan, Beth Y.; Gilks, Blake; Bowtell, David D.; Hogdall, Estrid; Candido dos Reis, Francisco J.; Steed, Helen; Campbell, Ian G.; Gronwald, Jacek; Benitez, Javier; Koziak, Jennifer M.; Chang-Claude, Jenny; Moysich, Kirsten B.; Kelemen, Linda E.; Cook, Linda S.; Goodman, Marc T.; Jose Garcia, Maria; Fasching, Peter A.; Kommoss, Stefan; Deen, Suha; Kjaer, Susanne K.; Menon, Usha; Brenton, James D.; Pharoah, Paul D. P.; Chenevix-Trench, Georgia; Huntsman, David G.; Winham, Stacey J.; Kobel, Martin; Ramus, Susan J.
Journal JAMA ONCOLOGY
Pages e173290
Volume 3
Date 1/12/2017
Grant ID MOP 86727
Funding Body Canadian Institutes for Health Research
URL http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1001/jamaoncol.2017.3290