QIMR Berghofer

Disease-Induced Alterations in Brain Drug Transporters in Animal Models of Alzheimer's Disease

Abstract

Alzheimer's disease (AD) may disturb functions of the blood-brain barrier and change the disposition of drugs to the brain. This study assessed the disease-induced changes in drug transporters in the brain capillaries of transgenic AD mice.

Authors Vellonen, Kati-Sisko; Ihalainen, Jouni; Boucau, Marie-Christine; Gosselet, Fabien; Picardat, Theo; Gynther, Mikko; Kanninen, Katja M.; White, Anthony R.; Malm, Tarja; Koistinaho, Jari; Forsberg, Markus M.; Ruponen, Marika
Journal PHARMACEUTICAL RESEARCH
Pages 2652-2662
Volume 34
Date 1/12/2017
Grant ID 257386
Funding Body Academy of Finland
URL http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1007/s11095-017-2263-7
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