QIMR Berghofer

Body mass index and breast cancer survival: a Mendelian randomization analysis

Abstract

There is increasing evidence that elevated body mass index (BMI) is associated with reduced survival for women with breast cancer. However, the underlying reasons remain unclear. We conducted a Mendelian randomization analysis to investigate a possible causal role of BMI in survival from breast cancer.

Authors Guo, Qi; Burgess, Stephen; Turman, Constance; Bolla, Manjeet K.; Wang, Qin; Lush, Michael; Abraham, Jean; Aittomaki, Kristiina; Andrulis, Irene L.; Apicella, Carmel; Arndt, Volker; Barrdahl, Myrto; Benitez, Javier; Berg, Christine D.; Blomqvist, Carl; Bojesen, Stig E.; Bonanni, Bernardo; Brand, Judith S.; Brenner, Hermann; Broeks, Annegien; Burwinkel, Barbara; Caldas, Carlos; Campa, Daniele; Canzian, Federico; Chang-Claude, Jenny; Chanock, Stephen J.; Chin, Suet-Feung; Couch, Fergus J.; Cox, Angela; Cross, Simon S.; Cybulski, Cezary; Czene, Kamila; Darabi, Hatef; Devilee, Peter; Diver, W. Ryan; Dunning, Alison M.; Earl, Helena M.; Eccles, Diana M.; Ekici, Arif B.; Eriksson, Mikael; Evans, D. Gareth; Fasching, Peter A.; Figueroa, Jonine; Flesch-Janys, Dieter; Flyger, Henrik; Gapstur, Susan M.; Gaudet, Mia M.; Giles, Graham G.; Glendon, Gord; Grip, Mervi; Gronwald, Jacek; Haeberle, Lothar; Haiman, Christopher A.; Hall, Per; Hamann, Ute; Hankinson, Susan; Hartikainen, Jaana M.; Hein, Alexander; Hiller, Louise; Hogervorst, Frans B.; Holleczek, Bernd; Hooning, Maartje J.; Hoover, Robert N.; Humphreys, Keith; Hunter, David J.; Husing, Anika; Jakubowska, Anna; Jukkola-Vuorinen, Arja; Kaaks, Rudolf; Kabisch, Maria; Kataja, Vesa; Knight, Julia A.; Koppert, Linetta B.; Kosma, Veli-Matti; Kristensen, Vessela N.; Lambrechts, Diether; Le Marchand, Loic; Li, Jingmei; Lindblom, Annika; Lindstrom, Sara; Lissowska, Jolanta; Lubinski, Jan; Machiela, Mitchell J.; Mannermaa, Arto; Manoukian, Siranoush; Margolin, Sara; Marme, Federik; Martens, John W. M.; McLean, Catriona; Menendez, Primitiva; Milne, Roger L.; Mulligan, Anna Marie; Muranen, Taru A.; Nevanlinna, Heli; Neven, Patrick; Nielsen, Sune F.; Nordestgaard, Borge G.; Olson, Janet E.; Perez, Jose I. A.; Peterlongo, Paolo; Phillips, Kelly-Anne; Poole, Christopher J.; Pylkas, Katri; Radice, Paolo; Rahman, Nazneen; Rudiger, Thomas; Rudolph, Anja; Sawyer, Elinor J.; Schumacher, Fredrick; Seibold, Petra; Seynaeve, Caroline; Shah, Mitul; Smeets, Ann; Southey, Melissa C.; Tollenaar, Rob A. E. M.; Tomlinson, Ian; Tsimiklis, Helen; Ulmer, Hans-Ulrich; Vachon, Celine; van den Ouweland, Ans M. W.; Van't Veer, Laura J.; Wildiers, Hans; Willett, Walter; Winqvist, Robert; Zamora, M. Pilar; Chenevix-Trench, Georgia; Dork, Thilo; Easton, Douglas F.; Garcia-Closas, Montserrat; Kraft, Peter; Hopper, John L.; Zheng, Wei; Schmidt, Marjanka K.; Pharoah, Paul D. P.
Journal INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
Pages 1814-1822
Volume 46
Date 1/12/2017
Grant ID P50 CA116201
Funding Body NCI NIH HHS
URL http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1093/ije/dyx131