Abstract

Background: Malignant mesothelioma (MM) is an aggressive cancer of the pleural and peritoneal cavities caused by exposure to asbestos. Asbestos-induced mesotheliomas in wild-type mice have been used extensively as a preclinical model because they are phenotypically identical to their human counterpart. However, it is not known if the genetic lesions in these mice tumours are similar to in the human disease, a prerequisite for any new preclinical studies that target genetic abnormalities.

Authors	Sneddon, Sophie; Patch, Ann-Marie; Dick, Ian M.; Kazakoff, Stephen; Pearson, John V.; Waddell, Nicola; Allcock, Richard J. N.; Holt, Robert A.; Robinson, Bruce W. S.; Creaney, Jenette
Journal	BMC CANCER
Pages
Volume	17
Date	1/06/2017
Grant ID
Funding Body	Housing Industry of Australia Charitable Foundation
URL	http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1186/s12885-017-3382-6