Abstract

The exposure of skin to ultraviolet (UV) radiation can have both beneficial and deleterious effects: it can lead, for instance, to increased pigmentation and vitamin D synthesis but also to inflammation and skin cancer. UVB may induce genetic and epigenetic alterations and have reversible effects associated with post-translational and gene regulation modifications. beta-catenin is a main driver in melanocyte development; although infrequently mutated in melanoma, its cellular localization and activity are frequently altered. Here, we evaluate the consequence of UVB on beta-catenin in the melanocyte lineage. We report that in vivo, UVB induces cytoplasmic/nuclear relocalization of beta-catenin in melanocytes of newborn mice and adult human skin. In mouse melanocyte and human melanoma cell lines in vitro, UVB increases beta-catenin stability, accumulation in the nucleus and cotranscriptional activity, leading to the repression of cell motility and velocity. The activation of the beta-catenin signalling pathway and its effect on migration by UVB are increased by an inhibitor of GSK3 beta, and decreased by an inhibitor of beta-catenin. In conclusion, UVB represses melanocyte migration and does so by acting through the GSK3-beta-catenin axis.

Authors	Bertrand, Juliette U.; Petit, Valerie; Hacker, Elke; Berlin, Irina; Hayward, Nicholas K.; Pouteaux, Marie; Sage, Evelyne; Whiteman, David C.; Larue, Lionel
Journal	EXPERIMENTAL DERMATOLOGY
Pages	875-882
Volume	26
Date	1/10/2017
Grant ID
Funding Body	Ligue contre le Cancer - comite de l'Oise
URL	http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1111/exd.13318