QIMR Berghofer

The First Plant 5,6-Secosteroid from the Australian Arid Zone Species Frankenia foliosa

Abstract

The first B-ring 5,6-secosteroid isolated from plants was obtained from Frankenia foliosa, growing in Australia's arid zone. This rare secosteroid was shown to be active against all cell lines including head and neck squamous cell carcinoma (SCC) cancer cell lines that contain the Cdc25A phosphatase protein.

Authors Tan, Yuen P.; Savchenko, Andrei I.; Broit, Natasa; Boyle, Glen M.; Parsons, Peter G.; Williams, Craig M.
Journal EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Pages 1498-1501
Volume
Date 1/03/2017
Grant ID
Funding Body EcoBiotics Ltd., the University of Queensland (UQ)
URL http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1002/ejoc.201700035