The First Casbane Hydroperoxides EBC-304 and EBC-320 from the Australian Rainforest
Abstract
Investigation of the Australian rainforest plant Croton insularis led to isolation of the first casbane hydroperoxide diterpenes EBC-304 and EBC-320. Extensive DFT and electronic circular dichroism (ECD) calculations in combination with 2D NMR spectroscopy determined the absolute configurations. EBC-304 and EBC-320 both display significant cytotoxicity.
| Authors | Maslovskaya, Lidiya A.; Savchenko, Andrei I.; Gordon, Victoria A.; Reddell, Paul W.; Pierce, Carly J.; Parsons, Peter G.; Williams, Craig M. |
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| Journal | CHEMISTRY-A EUROPEAN JOURNAL |
| Pages | 537-540 |
| Volume | 23 |
| Date | 1/01/2017 |
| Grant ID | |
| Funding Body | EcoBiotics Ltd. |
| URL | http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1002/chem.201604674 |