RAD51 is a vital component of the homologous recombination DNA repair pathway and is overexpressed in drug-resistant cancers, including aggressive triple negative breast cancer (TNBC). A proposed strategy for improving therapeutic outcomes for patients is through small molecule inhibition of RAD51, thereby sensitizing tumor cells to DNA damaging irradiation and/or chemotherapy. Here we report structure activity relationships for a library of quinazolinone derivatives. A novel RAD51 inhibitor (17) displays up to 15-fold enhanced inhibition of cell growth in a panel of TNBC cell lines compared to compound B02, and approximately 2-fold increased inhibition of irradiation-induced RAD51 foci formation. Additionally, compound 17 significantly inhibits TNBC cell sensitivity to DNA damage, implying a potentially targeted therapy for cancer treatment. Crown Copyright (C) 2017 Published by Elsevier Ltd. All rights reserved.
Authors | Ward, Ambber; Dong, Lilong; Harris, Jonathan M.; Khanna, Kum Kum; Al-Ejeh, Fares; Fairlie, David P.; Wiegmans, Adrian P.; Liu, Ligong |
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Journal | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS |
Pages | 3096-3100 |
Volume | 27 |
Date | 1/07/2017 |
Grant ID | 1117017 |
Funding Body | National Health and Medical Research Council of Australia (NHMRC) |
URL | http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1016/j.bmcl.2017.05.039 |