Background: The precise mechanism by which the immune system is adversely affected in cancer patients remains poorly understood, but the accumulation of immunosuppressive/protumorigenic myeloid-derived suppressor cells (MDSCs) is thought to be a prominent mechanism contributing to immunologic tolerance of malignant cells in epithelial ovarian cancer (EOC). To this end, we hypothesized genetic variation in MDSC pathway genes would be associated with survival after EOC diagnoses.
| Authors | Sucheston-Campbell, Lara E.; Cannioto, Rikki; Clay, Alyssa I.; Etter, John Lewis; Eng, Kevin H.; Liu, Song; Battaglia, Sebastiano; Hu, Qiang; Szender, J. Brian; Minlikeeva, Albina; Joseph, Janine M.; Mayor, Paul; Abrams, Scott I.; Segal, Brahm H.; Wallace, Paul K.; Soh, Kah Teong; Zsiros, Emese; Anton-Culver, Hoda; Bandera, Elisa V.; Beckmann, Matthias W.; Berchuck, Andrew; Bjorge, Line; Bruegl, Amanda; Campbell, Ian G.; Campbell, Shawn Patrice; Chenevix-Trench, Georgia; Cramer, Daniel W.; Dansonka-Mieszkowska, Agnieszka; Dao, Fanny; Diergaarde, Brenda; Doerk, Thilo; Doherty, Jennifer A.; du Bois, Andreas; Eccles, Diana; Engelholm, Svend Aage; Fasching, Peter A.; Gayther, Simon A.; Gentry-Maharaj, Aleksandra; Glasspool, Rosalind M.; Goodman, Marc T.; Gronwald, Jacek; Harter, Philipp; Hein, Alexander; Heitz, Florian; Hillemmanns, Peter; Hogdall, Claus; Hogdall, Estrid V. S.; Huzarski, Tomasz; Jensen, Allan; Johnatty, Sharon E.; Jung, Audrey; Karlan, Beth Y.; Klapdor, Reudiger; Kluz, Tomasz; Konopka, Bozena; Kjaer, Susanne Krueger; Kupryjanczyk, Jolanta; Lambrechts, Diether; Lester, Jenny; Lubinski, Jan; Levine, Douglas A.; Lundvall, Lene; McGuire, Valerie; McNeish, Iain A.; Menon, Usha; Modugno, Francesmary; Ness, Roberta B.; Orsulic, Sandra; Paul, James; Pearce, Celeste Leigh; Pejovic, Tanja; Pharoah, Paul; Ramus, Susan J.; Rothstein, Joseph; Rossing, Mary Anne; Ruebner, Matthias; Schildkraut, Joellen M.; Schmalfeldt, Barbara; Schwaab, Ira; Siddiqui, Nadeem; Sieh, Weiva; Sobiczewski, Piotr; Song, Honglin; Terry, Kathryn L.; Van Nieuwenhuysen, Els; Vanderstichele, Adriaan; Vergote, Ignace; Walsh, Christine S.; Webb, Penelope M.; Wentzensen, Nicolas; Whittemore, Alice S.; Wu, Anna H.; Ziogas, Argyrios; Odunsi, Kunle; Chang-Claude, Jenny; Goode, Ellen L.; Moysich, Kirsten B. |
|---|---|
| Journal | CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION |
| Pages | 420-424 |
| Volume | 26 |
| Date | 1/03/2017 |
| Grant ID | |
| Funding Body | Ovarian Cancer Research Fund |
| URL | http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1158/1055-9965.EPI-16-0631 |