QIMR Berghofer

Gene silencing by RNA interference in Sarcoptes scabiei: a molecular tool to identify novel therapeutic targets


Background: Scabies is one of the most common and widespread parasitic skin infections globally, affecting a large range of mammals including humans, yet the molecular biology of Sarcoptes scabiei is astonishingly understudied. Research has been hampered primarily due to the difficulty of sampling or culturing these obligatory parasitic mites. A further and major impediment to identify and functionally analyse potential therapeutic targets from the recently emerging molecular databases is the lack of appropriate molecular tools.

Authors Fernando, Deepani D.; Marr, Edward J.; Zakrzewski, Martha; Reynolds, Simone L.; Burgess, Stewart T. G.; Fischer, Katja
Volume 10
Date 1/06/2017
Grant ID 1067192
Funding Body Australian Government National Health and Medical Research Council
URL http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1186/s13071-017-2226-1