Breast cancer risk prediction using a polygenic risk score in the familial setting: a prospective study from the Breast Cancer Family Registry and kConFab

Abstract

Purpose: This study examined the utility of sets of single-nucleotide polymorphisms (SNPs) in familial but non-BRCA-associated breast cancer (BC).

Authors Li, Hongyan; Feng, Bingjian; Miron, Alexander; Chen, Xiaoqing; Beesley, Jonathan; Bimeh, Emmanuella; Barrowdale, Daniel; John, Esther M.; Daly, Mary B.; Andrulis, Irene L.; Buys, Saundra S.; Kraft, Peter; Thorne, Heather; Chenevix-Trench, Georgia; Southey, Melissa C.; Antoniou, Antonis C.; James, Paul A.; Terry, Mary Beth; Phillips, Kelly-Anne; Hopper, John L.; Mitchell, Gillian; Goldgar, David E.
Journal GENETICS IN MEDICINE
Pages 30-35
Volume 19
Date 1/01/2017
Grant ID 566791
Funding Body Cancer Australia's Priority-driven Collaborative Cancer Research Scheme
URL http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1038/gim.2016.43