There is a growing association of human papillomavirus (HPV) with some cases of mucosal squamous cell carcinoma of the head and neck (HNSCC), particularly of the oropharynx. Persistent oral HPV infection is believed to increase the likelihood of malignancy, and it is possible that host genetic factors can determine susceptibility to persistent HPV infection. Polymorphisms in the two EV genes (EVER1 and EVER2, also known as transmembrane channel protein (TMC) 6 and 8) have been identified as strong candidate genes, since a small number of critical mutations in these genes have been shown to cause profound and florid skin HPV infections, and some of them have been linked to susceptibility to cervical cancer.
Authors | Antonsson, Annika; Law, Matthew H.; Neale, Rachel E.; Coman, William B.; Pryor, David I.; Porceddu, Sandro V.; Whiteman, David C. |
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Journal | CANCER CAUSES CONTROL |
Pages | 809-815 |
Volume | 27 |
Date | 1/07/2016 |
Grant ID | APP1006480 |
Funding Body | National Health and Medical Research Council of Australia (NHMRC) |
URL | http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1007/s10552-016-0749-y |