seco-Casbanes from the Australian Rainforest: ECD Predictions Key for Determining Remote Absolute Configuration
Abstract
The seco-casbane framework, first isolated from Croton insularis, is surprisingly rare. Further evaluation of this Australian rainforest plant unearthed two additional members, EBC-328 and EBC-363. TD DFT predicted electronic circular dichroism (ECD) spectra were critical for remote absolute stereochemical determination. EBC-328 displayed cytotoxic activity towards leukemia cells (K562). Potential biosynthetic relationships are discussed.
| Authors | Maslovskaya, Lidia A.; Savchenko, Andrei I.; Gordon, Victoria A.; Reddell, Paul W.; Pierce, Carly J.; Parsons, Peter G.; Williams, Craig M. |
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| Journal | EUROPEAN JOURNAL OF ORGANIC CHEMISTRY |
| Pages | 1673-1677 |
| Volume | |
| Date | 1/03/2016 |
| Grant ID | |
| Funding Body | EcoBiotics Ltd. |
| URL | http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1002/ejoc.201501605 |