High content screening application for cell-type specific behaviour in heterogeneous primary breast epithelial subpopulations
Abstract
Background: The complex interaction between multiple cell types and the microenvironment underlies the diverse pathways to carcinogenesis and necessitates sophisticated approaches to in vitro hypotheses testing. The combination of mixed culture format with high content immunofluorescence screening technology provides a powerful platform for observation of cell type specific behavior.
| Authors | Johnston, Rebecca L.; Wockner, Leesa; Reed, Amy E. McCart; Wiegmans, Adrian; Chenevix-Trench, Georgia; Khanna, Kum Kum; Lakhani, Sunil R.; Smart, Chanel E. |
|---|---|
| Journal | BREAST CANCER RESEARCH |
| Pages | |
| Volume | 18 |
| Date | 1/02/2016 |
| Grant ID | |
| Funding Body | Australian National Breast Cancer Foundation Novel Concept Award |
| URL | http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1186/s13058-016-0681-9 |