QIMR Berghofer

Bone marrow-derived and resident liver macrophages display unique transcriptomic signatures but similar biological functions

Abstract

Background & Aims: Kupffer cells (KCs), the resident tissue macrophages of the liver, play a crucial role in the clearance of pathogens and other particulate materials that reach the systemic circulation. Recent studies have identified KCs as a yolk sac-derived resident macrophage population that is replenished independently of monocytes in the steady state. Although it is now established that following local tissue injury, bone marrow derived monocytes may infiltrate the tissue and differentiate into macrophages, the extent to which newly differentiated macrophages functionally resemble the KCs they have replaced has not been extensively studied.

Authors Beattie, Lynette; Sawtell, Amy; Mann, Jason; Frame, Teija C. M.; Teal, Bianca; Rivera, Fabian de Labastida; Brown, Najmeeyah; Walwyn-Brown, Katherine; Moore, John W. J.; MacDonald, Sandy; Lim, Eng-Kiat; Dalton, Jane E.; Engwerda, Christian R.; MacDonald, Kelli P.; Kaye, Paul M.
Journal JOURNAL OF HEPATOLOGY
Pages 758-768
Volume 65
Date 1/10/2016
Grant ID G0802620
Funding Body UK Medical Research Council
URL http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1016/j.jhep.2016.05.037
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