Normal fetal neurological development depends on a regulated supply of maternal thyroid hormone (TH). We have previously demonstrated that transthyretin (TTR) a TH binding protein, is synthesized, secreted and internalized by trophoblast cells and may provide a route for the transfer of TH from mother to fetus. Our objective was to determine if a member of the low-density lipoprotein receptor family mediates TTR or TTR-TH internalization. TTR-TH internalization by JEG-3 cells is reduced in the presence of receptor associated protein (RAP) or albumin suggesting that TTR-TH is internalized through an LDL-receptor dependent endocytic process.
| Authors | Landers, K.; Li, H.; Subramaniam, VN; Mortimer, R. H.; Richard, K. |
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| Journal | PLACENTA |
| Pages | 716-8 |
| Volume | 34 |
| Date | 1/08/2013 |
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| URL | http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1016/j.placenta.2013.05.005 |