EBC-219 (4), isolated from Croton insularis (Baill), was established by spectroscopic and DFT methods as the first member of a new diterpene skeletal class, uniquely defined by the presence of a bicyclo[10.2.1] bridgehead olefin. The proposed biogenetic pathway to 4 from the co-isolated natural products EBC-131 (1), EBC-180 (2) and EBC-181 (3) is highly likely. EBC-180 (2) and EBC-181 (3) showed moderate to strong cytotoxic activity against various cancer cell lines.
| Authors | Maslovskaya, Lidiya A.; Savchenko, Andrei I.; Krenske, Elizabeth H.; Pierce, Carly J.; Gordon, Victoria A.; Reddell, Paul; Parsons, PG; Williams, Craig M. |
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| Journal | Angewandte Chemie |
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| Date | 1/05/2014 |
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| Funding Body | Ecobiotics |
| URL | http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1002/anie.201310923 |
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